Akt Gene, GeneCards - The Human Gene Compendium AKT1, do inglês V-akt murine thymoma viral oncogene homolog 1, é uma enzima que em humanos é codificada pelo gene AKT1. The Akt protein kinase family comprises three highly related isoforms encoded AKT1 protein expression summary - The Human Protein Atlas 3. AKT is a critical signaling node The Genome Browser is protecting itself from bots. Akt is a PI3K-activated serine-threonine kinase that exists in three distinct isoforms. Abstract. Learn about this gene and related health conditions. AKT1 is one of 3 closely related serine/threonine-protein kinases (AKT1, AKT2 and AKT3) called the AKT kinase, and which regulate many processes including metabolism, proliferation, cell survival, growth and angiogenesis (PubMed:11882383, PubMed:15526160, PubMed:15861136, PubMed:21432781, PubMed:21620960, PubMed:31204173). 2 The AKT serine/threonine kinase 1 gene: AKT1 AKT1 is a gene located on chromosome 14q32, coding for protein kinase B called AKT1. The Akt family of serine/threonine protein kinases are key regulators of multiple aspects of cell behaviour, including proliferation, survival, metabolism, and tumorigenesis. Inhibition of the PIK3 AKT pathway or mutation of the AKT site on eNOS protein at serine-1177 attenuated the serine phosphorylation and prevented the activation of eNOS. A look at AKT shows that there is still much more to learn about this central signaling kinase. Growth-factor-activated Akt signalling promotes progression through Explore the Akt pathway that mediates apoptosis and cell proliferation. The mammalian v-akt murine thymoma viral oncogene homolog (AKT) belongs to the protein kinase A, kinase G, and kinase C superfamily of serine/threonine kinases. Therefore, the letters of the gene likely stand for the same. Conserved from primitive metazoans to humans, PKB belongs to the AGC subfamily of the protein kinase superfamily, which consists of 518 members in humans AKT (AK mouse plus Transforming or Thymoma) is a common oncogene expressed in most tissues. Genotoxic Agents AKT signaling is integral to cell survival, particularly in the transformed setting. The AKT3 gene provides instructions for making a protein that is most active in the nervous system. Create science figures in minutes with BioRender scientific illustration software! AKT1 is one of 3 closely related serine/threonine-protein kinases (AKT1, AKT2 and AKT3) called the AKT kinase, and which regulate many processes including metabolism, proliferation, cell survival, growth and angiogenesis (PubMed:11882383, PubMed:15526160, PubMed:15861136, PubMed:21432781, PubMed:21620960, PubMed:31204173). Their provisional set of biological capabilities acquired during tumor development—cancer hallmarks—would evolve to 14 tenets as knowledge of cancer genomes, molecular mechanisms, and the tumor microenvironment expanded, most recently Explore the Akt pathway that mediates apoptosis and cell proliferation. The viral oncogene isolated from the AKT-8 was named v- akt. AKT is a critical signaling node AKT (AK mouse plus Transforming or Thymoma) is a common oncogene expressed in most tissues. While Akt is most highly expressed in innate immune cells, it plays crucial roles in Gene target information for AKT1 - AKT serine/threonine kinase 1 (human). The presence of mutant AKT1 (the encoding gene for AKT1) amplifies the adaptive response to BRAFi in melanoma cells harbouring BRAFV600 mutations [3,50]. (1999) demonstrated that AKT mediates the activation of eNOS, leading to increased nitric oxide production. This is mediated through serine and/or threonine phosphorylation of a Dimmeler et al. Among the signalling proteins that respond to a large variety of signals, protein kinase B (PKB, also known as Akt) appears to be a central player in regulation of metabolism, cell survival, motility, transcription and cell-cycle progression. , 2010). Growth-factor-activated Akt is a protein kinase — an enzyme that adds a phosphate group to other proteins to modulate their function, acting at a specific recognition site in the target protein. Mutations in the gene can cause Proteus syndrome, some types of cancer, and may be involved in schizophrenia. Anomalies of Akt genes were described for a variety of human cancers; Akt1 gene amplifications have been reported in gastric carcinoma, glioblastomas and gliosarcomas, whereas Akt2 amplification has been identified in head and neck squamous cell carcinoma, pancreatic, ovarian and breast cancers (45). Find diseases associated with this biological target and compounds tested against it in bioassay experiments. GeneCards - The Human Gene Compendium The AKT1 gene provides instructions for making a protein called AKT1 kinase. The Akt-FRET biosensor mouse reveals live spatiotemporal regulation in cancer, metabolism and whole-body molecular targeting. Browse 1000s of icons & templates from many fields of life sciences. Jan 14, 2026 · AKT1 is a protein kinase that regulates cellular functions such as proliferation, survival, metabolism, and angiogenesis. There are three known Akt isoforms which play critical and diverse roles in the cardiovascular system. Akt/PKB is a key master regulator of a wide range of physiological functions including metabolism, proliferation, survival, growth, angiogenesis and migration and invasion. AKT2 (AKT Serine/Threonine Kinase 2) is a Protein Coding gene. The AKT1 gene provides instructions for making a protein that regulates cell growth, survival, and differentiation. AKT, or protein kinase B, is a central node of the PI3K signaling pathway that is pivotal for a range of normal cellular physiologies that also underlie several pathological conditions, including inflammatory and autoimmune diseases, overgrowth syndromes, and neoplastic transformation. These highly similar AKT proteins all have an N-terminal pleckstrin homology domain, a serine/threonine-specific kinase domain and a C-terminal regulatory domain. AKT1 gene information - The Human Protein Atlas Akt kinase, a member of AGC kinases, is important in many cellular functions including proliferation, migration, cell growth and metabolism. AKT kinases are known to be regulators of cell signaling in response to insulin and growth factors. These pathologies, notably cancer, arise if either the activity of AKT or its positive or negative upstream The serine/threonine kinase AKT functions as a critical mediator of signaling downstream of PI3 kinase. 1. These pathologies, notably cancer, arise if either the activity of AKT or its positive or negative upstream PIP 3 を介して正しく膜に配置されたAktは、 PDPK1 （英語版） （phosphoinositide dependent kinase 1）によって スレオニン 308番残基が、 mTORC2 （mammalian target of rapamycin complex 2）によって セリン 473番残基がリン酸化されて活性化されるが [10][11] 、最初に起こるのはmTORC2 Complete information for AKT1S1 gene (Protein Coding), AKT1 Substrate 1, including: function, proteins, disorders, pathways, orthologs, and expression. The phosphoinositide 3-kinase (PI3K)-Akt-mammalian target of rapamycin (mTOR) pathway (PI3K-Akt-mTOR pathway), vital for intracellular signaling, is associated with various cellular functions 1, 2. Akt’s expression in most immune cells, either at baseline or upon activation, reflects its importance in the immune system. RAC (Rho family)-alpha serine/threonine-protein kinase is an enzyme that in humans is encoded by the AKT1 gene. The combination of an AKT inhibitor with dabrafenib or/and trametinib-induced apoptosis in cells sensitive to the AKT inhibitor. Learn how its signaling activity is vital for health and how its dysregulation can contribute to human disease. . Among its related pathways are IL-9 Signaling Pathwaysand Translation Insulin regulation of translation. Nearly a quarter century ago, Hanahan and Weinberg conceived six unifying principles explaining how normal cells transform into malignant tumors. This enzyme belongs to the AKT subfamily of serine/threonine kinases that contain SH2 (Src homology 2-like) protein domains. The regulation of all three genes Akt kinase, a member of AGC kinases, is important in many cellular functions including proliferation, migration, cell growth and metabolism. The regulation of all three genes depends on two receptors-a receptor tyrosine kinase with a growth factor ligand, and a G protein coup … A gene ontology (GO) classification of the Akt1 interactome revealed that a significant number of the component proteins were derived from functional classes that related either to cell growth, or The serine/threonine kinase Akt, also known as protein kinase B (PKB), is a central node in cell signaling downstream of growth factors, cytokines, and other cellular stimuli. Akt Complete information for HIF1A gene (Protein Coding), Hypoxia Inducible Factor 1 Subunit Alpha, including: function, proteins, disorders, pathways, orthologs, and expression. This is mediated through serine and/or threonine phosphorylation of a Dec 1, 2025 · The serine/threonine kinase AKT is a central signaling node frequently dysregulated in cancer, integrating inputs from both canonical PI3K-dependent and alternative activation pathways to drive tumorigenesis. Protein kinase B (Akt), similar to many other protein kinases, is at the crossroads of cell death and survival, playing a pivotal role in multiple interconnected cell signaling mechanisms implicated in cell metabolism, growth and division, apoptosis In 1992, the first recurrent alterations of an AKT gene were identified in human cancer, with the demonstration of amplification and overexpression of AKT2 in a subset of ovarian carcinomas (Cheng Explore the Akt pathway that mediates apoptosis and cell proliferation. Complete information for AKT1 gene (Protein Coding), AKT Serine/Threonine Kinase 1, including: function, proteins, disorders, pathways, orthologs, and expression. Of note, BRCA1 (breast cancer susceptibility gene 1), a tumor suppressor with E3 ligase activity, interacted with phosphorylated Akt at T308 and S473 and triggered K48-linked ubiquitination and proteasome degradation of Akt especially in nucleus [40]. We have carried out a systematic evaluation of clinical AKT inhibitors using in vitro pharmacology, molecular profiling and biochemical assays together with structural modelling to better Summary This gene encodes one of the three members of the human AKT serine-threonine protein kinase family which are often referred to as protein kinase B alpha, beta, and gamma. Find antibodies to detect target proteins, including Akt, p70 S6K, CREB, and p53. This will just take a few seconds. This protein is involved in a number of important cellular processes such as cell survival, cell cycle regulation, apoptosis, size and glucose metabolism (Freyberg et al. Studies over the last two decades have firmly established the importance of AKT in the regulation of cell survival, proliferation, and insulin-dependent metabolic Summaries for AKT3 Gene NCBI Gene Summary for AKT3 Gene The protein encoded by this gene is a member of the AKT, also called PKB, serine/threonine protein kinase family. In this review, we systematically summarize the complex regulatory mechanisms governing AKT activation, with a focus on oncogenic alterations such as PIK3CA mutations and PTEN loss The AKT1 gene produces a protein that is a central regulator of cell survival and growth. Akt Discover the AKT protein’s fundamental role in cellular processes, its critical impact on health, and its significance for future medical advancements. Both AKT2 and AKT3, although important, have more limited distributions. Aberrant loss or gain of Akt activation underlies the pathophysiological properties of a variety of complex diseases, including type-2 diabetes and cancer. It is involved in many signalling pathways and is a target of mutations in various cancers and syndromes. Here, we review the molecular properties of Akt and the AKT, or protein kinase B, is a central node of the PI3K signaling pathway that is pivotal for a range of normal cellular physiologies that also underlie several pathological conditions, including inflammatory and autoimmune diseases, overgrowth syndromes, and neoplastic transformation. A proteína quinase serina / treonina codificada pelo gene AKT1 está cataliticamente inactiva em fibroblastos privados de soro e em fibroblastos imortalizados. [5] It is commonly referred to as PKB, or by both names as "Akt/PKB". GeneCards - The Human Gene Compendium Akt signaling refers to the activation of protein kinase B (Akt) by upstream phosphoinositide 3-kinase (PI3K), which regulates downstream effector molecules through phosphorylation cascades, playing a crucial role in various biological functions and providing neuroprotection by limiting apoptosis and controlling oxidative stress levels. Gene Ontology (GO) annotations related to this gene include transferase activity Summaries for AKT3 Gene NCBI Gene Summary for AKT3 Gene The protein encoded by this gene is a member of the AKT, also called PKB, serine/threonine protein kinase family. The Akt signaling pathway or PI3K-Akt signaling pathway is a signal transduction pathway that promotes survival and growth in response to extracellular signals. In addition to the classic model of AKT activation via growth factor signaling or loss of tumor suppressor phosphatases, AKT may also be activated in response to genotoxic insults induced by traditional chemotherapies. Diseases associated with AKT2 include Hypoinsulinemic Hypoglycemia With Hemihypertrophyand Akt2-Related Familial Partial Lipodystrophy. Dec 10, 2024 · Summary This gene encodes one of the three members of the human AKT serine-threonine protein kinase family which are often referred to as protein kinase B alpha, beta, and gamma. 12xh, h0qi, 0krhku, 4law, jmq8, javm, 3fe2m, oqj4w, 8wil, tj9cg,